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Abstract #0042

Brain Microstructural Changes Support Cognitive Deficits in Normal Children Born to HIV-infected Mothers

Santosh Kumar Yadav1, Rakesh K Gupta2, Sabah N Ahmed1, Sheema Hashem1, Ajaz A Bhat1, Ravindra K Garg3, Vimala Venkatesh4, Muhammad W Azeem5, and Mohammad Haris1,6

1Division of Translational Medicine, Sidra Medicine, Doha, Qatar, 2Department of Radiology and Imaging, Fortis Memorial Research Institute, Gurgaon, India, 3Department of Neurology, King George Medical University, Lucknow, India, 4Department of Microbiology, King George Medical University, Lucknow, India, 5Department of Psychiatry, Sidra Medicine, Doha, Qatar, 6Laboratory Animal Research Center, Qatar University, Doha, Qatar

In the current study, we evaluated the brain integrity [by mapping the fractional anisotropy (FA) and mean diffusivity (MD)] and neurocognitive performance (NP) in normal children (NCI) born to HIV-infected mother compared to normal children (NCH) born to healthy mother and HIV-infected children (HI). Reduced FA in multiple brain sites of HI and NCI children suggests loss of tissue integrity while altered MD indicates presence of cerebral edema. Presence of tissue changes and abnormal cognition in absence of HIV-infection in NCI children advice that ART may have detrimental effects on brain.

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