Abstract #0043

Anomalous relationship between sensorimotor GABA levels and cortical excitability in children with Attention-deficit/hyperactivity disorder

Ashley D Harris^1,2,3, David A Huddleston⁴, Paul S Horn⁴, Kim M Cecil⁵, Richard AE Edden^6,7, Donald L Gilbert⁴, Stewart H Mostofsky^8,9,10, and Nicolaas AJ Puts^6,7

¹Radiology, University of Calgary, Calgary, AB, Canada, ²Child and Adolescent Imaging Research Program, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada, ³Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada, ⁴Division of Pediatric Neurology, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH, United States, ⁵Department of Radiology, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH, United States, ⁶Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins School of Medicine, Baltimore, MD, United States, ⁷F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ⁸Center forNeurocognitive and Imaging Research, Kennedy Krieger Institute, Baltimore, MD, United States, ⁹Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, United States, ¹⁰Department of Behavioral Science and Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD, United States

Reduced inhibition as shown though GABA-edited MRS and TMS measures have been suggested to underlie some of the symptomology of ADHD. In this study we apply GABA-MRS and single- and paired-pulse TMS in ADHD and typically developing cohorts to better understand altered inhibition in ADHD. We show that SICI approaches 1 with increasing GABA across both groups. Secondly, we show a convergence in SICI and single-pulse TMS responses with increasing GABA. Last, we show different factors modulate the TMS responses between ADHD and control suggesting there are additional differences in GABAergic inhibition between these two groups.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.