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Abstract #0044

The Relation Between Nasal Nitric Oxide and Neurocognitive Outcome is Mediated by Regional Cerebral Blood Flow in Healthy Adolescents and Adolescents with Congenital Heart Disease

Vincent Jerome Schmithorst1, Ashok Panigrahy1, Philip Adams2, and Cecilia Lo2

1Radiology, UPMC Pittsburgh Children's Hospital, Pittsburgh, PA, United States, 2UPMC Pittsburgh Children's Hospital, Pittsburgh, PA, United States

Nasal nitric oxide (nNO) may be a proxy for NO or NO synthase (NOS) availability in the brain, while NO/NOS availability is likely related to metabolism and downstream to neurocognitive function. We tested this hypothesis using a mediation analysis with nNO the independent variable, regional CBF (rCBF) as measured by ASL the mediator, and neurocognitive outcome (NIH Toolbox) the dependent variable in a cohort of normal adolescents and adolescents with congenital heart disease. Anterior and posterior default mode network regions positively mediated all NIH Toolbox composite scores, especially crystallized cognition. Results indicate nNO may be a powerful biomarker for brain function and metabolism.

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