Abstract #0045

Investigating the effects of an early intervention in preterm newborns: A resting-state functional connectivity study

Serafeim Loukas^1,2, Djalel E Meskaldji^1,3, Lara Lordier¹, Joana Sa de Almeida¹, Dimitri Van De Ville², and Petra S Huppi¹

¹Division of Development and Growth, Department of Pediatrics, University of Geneva, Geneva, Switzerland, ²Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne, Switzerland, ³Institute of Mathematics, Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne, Switzerland

In this study we explore the effects of an early intervention on functional connectivity in preterm newborns. A group of preterm newborns underwent musical intervention in NICU during hospitalization. At TEA, two resting-state fMRI runs were collected. The first was before and the second after the presentation of the same musical stimulus used for the early intervention. We construct the functional connectomes using Accordance and we employ connectome-based statistical methods to unveil changes in functional connectivity evoked by this familiar musical stimulus. Increased connectivity is observed in key brain areas involved in music and emotion processing supporting previous findings.

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