Abstract #0047

Dynamic Deuterium MRS Imaging for Studying Rat Heart Energy Metabolism in vivo – Initial Experience

Huan Li^1,2, Xiao-Hong Zhu¹, Wei Zhu¹, Byeong-Yeul Lee¹, Hannes Michel Wiesner¹, Yi Zhang¹, Tao Wang¹, and Wei Chen¹

¹Center for Magnetic Resonance Research,Department of Radiology, University of Minnesota, Minneapolis, MN, United States, Minneapolis, MN, United States, ²Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China

Assessment of myocardial energy metabolism is crucial for understanding heart function and viable myocardium after myocardial infarction. Based on our recently developed in vivo Deuterium (²H) MR spectroscopic (DMRS) approach, we further exploited the DMRS and imaging (DMRSI) methods for dynamic measurement of the myocardial energy metabolism in rat heart at 16.4 T. This work demonstrates the feasibility of in vivo DMRS for assessing myocardial energy metabolisms, and its potential to directly image the viable myocardium in hearts under conditions such as myocardial infarction.

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