Meeting Banner
Abstract #0048

High-resolution phosphocreatine mapping of human skeletal muscle by artificial neural network-based chemical exchange saturation transfer MRI at 3T

Lin Chen1,2, Michael Schär2,3, Kannie W.Y. Chan1,2,4, Jianpan Huang4, Zhiliang Wei1,2, Hanzhang Lu1,2, Qin Qin1,2, Robert G. Weiss2,3, Peter C.M. van Zijl1,2, and Jiadi Xu1,2

1F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States, 2Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3Division of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, China

The creatine kinase reaction provides energy for cells by reversibly regenerating adenosine triphosphate from a phosphocreatine pool. Functional impairment of this system is observed in many neurodegenerative and muscle diseases. In this study, we developed a high-resolution phosphocreatine (PCr) mapping approach that can be used on standard magnetic resonance clinical scanners by specifically detecting PCr via the water proton signal using a chemical exchange saturation transfer (CEST) method. An artificial neural network was employed to achieve absolute quantification of PCr concentration. Such a mapping method offers a non-invasive, rapid imaging tool to quantify abnormalities in PCr content and distribution in musculoskeletal diseases.

This abstract and the presentation materials are available to members only; a login is required.

Join Here