Abstract #0049

Translating pH-sensitive PROgressive saturation for Quantifying Exchange using Saturation Times (PRO-QUEST) MRI to a 3T Clinical Scanner

Mina Kim¹, Marco Battiston², Eleni Demetriou¹, Aaron Kujawa¹, Torben Schneider³, Vincent Evans⁴, Sachi Okuchi¹, David Atkinson⁴, Claudia Wheeler-Kingshott^2,5,6, and Xavier Golay¹

¹Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, ²Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, ³Philips Healthcare, Surrey, United Kingdom, ⁴UCL Centre for Medical Imaging, University College London, London, United Kingdom, ⁵Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, ⁶Brain MRI 3T Research Centre, IRCCS Mondino Foundation, Pavia, Italy

In this work, a recently developed method called PRO-QUEST (PROgressive saturation for Quantifying Exchange using Saturation Times) is translated to a 3T clinical scanner for assessing pH-sensitive indices in phantoms and a healthy volunteer. Our results demonstrate that quantification of pH sensitive indices using PRO-QUEST is feasible at 3T within clinically acceptable acquisition times. Our initial findings suggest that PRO-QUEST has the potential to provide a new biomarker to study neurological disorders associated with brain tissue acidosis.

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