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Abstract #0056

Estimating compartment- and cell-specific microscopic anisotropy in the human brain using double-diffusion encoding spectroscopy at 7T

Chloé Najac1, Henrik Lundell2, Marjolein Bulk1, Hermien E. Kan1, Andrew G. Webb1, and Itamar Ronen1

1Radiology, C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden, Netherlands, 2Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark

Double diffusion encoding spectroscopy (DDES) offers the unique ability to estimate compartment and cell-specific micro-anisotropy (μFA) in vivo. Recently, this method allowed the estimation of intracellular micro-anisotropy in the white matter. Here, we propose to measure the μFA in different diffusion weighting settings to explore intra- and extracellular μFA in both white (WM) and grey matter (GM). We show that intracellular μFA is similar in both WM and GM, but extracellular space in WM is significantly more anisotropic compared to GM.

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