Abstract #0056

Estimating compartment- and cell-specific microscopic anisotropy in the human brain using double-diffusion encoding spectroscopy at 7T

Chloé Najac¹, Henrik Lundell², Marjolein Bulk¹, Hermien E. Kan¹, Andrew G. Webb¹, and Itamar Ronen¹

¹Radiology, C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden, Netherlands, ²Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark

Double diffusion encoding spectroscopy (DDES) offers the unique ability to estimate compartment and cell-specific micro-anisotropy (μFA) in vivo. Recently, this method allowed the estimation of intracellular micro-anisotropy in the white matter. Here, we propose to measure the μFA in different diffusion weighting settings to explore intra- and extracellular μFA in both white (WM) and grey matter (GM). We show that intracellular μFA is similar in both WM and GM, but extracellular space in WM is significantly more anisotropic compared to GM.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.