Double diffusion encoding spectroscopy (DDES) offers the unique ability to estimate compartment and cell-specific micro-anisotropy (μFA) in vivo. Recently, this method allowed the estimation of intracellular micro-anisotropy in the white matter. Here, we propose to measure the μFA in different diffusion weighting settings to explore intra- and extracellular μFA in both white (WM) and grey matter (GM). We show that intracellular μFA is similar in both WM and GM, but extracellular space in WM is significantly more anisotropic compared to GM.
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