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Abstract #0057

MRS Extended by Oscillating Diffusion Gradients as a Probe for Investigation of Human Brain Tissue Microstructure

André Döring1 and Roland Kreis1

1Depts. Radiology and Biomedical Research, Bern, Switzerland

Pulsed diffusion and oscillating diffusion gradients implemented in a semi-Laser sequence for measuring at long and short diffusion times were tested in a phantom and applied in vivo. Metabolite diffusion constants measured in human gray matter in 6 healthy volunteers at short diffusion times were significantly higher than those determined at long diffusion times, suggesting an enhanced sensitivity to diffusion on the cellular and subcellular level.

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