Abstract #0058

Oscillating-gradient diffusion-weighted MRI provides accurate cell radii in tumor spheroids

Marcel Kettelmann¹, Stephan Niland², Mirjam Gerwing¹, Markus Wick³, Sascha Koehler³, Lydia Wachsmuth¹, Moritz Wildgruber¹, Johannes A Eble², and Cornelius Faber¹

¹Translational Research Imaging Center (TRIC), University Hospital Muenster, Muenster, Germany, ²Institute of Physiological Chemistry and Pathobiochemistry, University Hospital Muenster, Muenster, Germany, ³Bruker BioSpin, Ettlingen, Germany

Diffusion weighted MRI using oscillating gradients has previously been shown to provide microstructural information on celllularity in tumors, which may serve as marker for monitoring therapy response. Which geometrical model for analysis of such data provides most reliable results, is, however, a matter of debate. Here, we used the IMPULSED approach, and show that cell radii in tumor spheroids of three different cell lines can be determined with high accuracy. In an in vivo model, however, deviations from radii determined by laser scanning microscopy were found.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.