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Abstract #0058

Oscillating-gradient diffusion-weighted MRI provides accurate cell radii in tumor spheroids

Marcel Kettelmann1, Stephan Niland2, Mirjam Gerwing1, Markus Wick3, Sascha Koehler3, Lydia Wachsmuth1, Moritz Wildgruber1, Johannes A Eble2, and Cornelius Faber1

1Translational Research Imaging Center (TRIC), University Hospital Muenster, Muenster, Germany, 2Institute of Physiological Chemistry and Pathobiochemistry, University Hospital Muenster, Muenster, Germany, 3Bruker BioSpin, Ettlingen, Germany

Diffusion weighted MRI using oscillating gradients has previously been shown to provide microstructural information on celllularity in tumors, which may serve as marker for monitoring therapy response. Which geometrical model for analysis of such data provides most reliable results, is, however, a matter of debate. Here, we used the IMPULSED approach, and show that cell radii in tumor spheroids of three different cell lines can be determined with high accuracy. In an in vivo model, however, deviations from radii determined by laser scanning microscopy were found.

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