Abstract #0062

Tangential and radial diffusion in human primary somatosensory and motor cortex: evidence from in-vivo line-scan acquisitions at 7T with 250–500 micron radial resolution

Mukund Balasubramanian^1,2, Robert V. Mulkern^1,2, Stephan E. Maier^1,3,4, and Jonathan R. Polimeni^1,5,6

¹Harvard Medical School, Boston, MA, United States, ²Department of Radiology, Boston Children's Hospital, Boston, MA, United States, ³Department of Radiology, Brigham and Women's Hospital, Boston, MA, United States, ⁴Department of Radiology, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden, ⁵Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, ⁶Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States

Eight healthy volunteers were scanned at 7T using a line-scan diffusion sequence with each line prescribed perpendicularly to primary somatosensory (S1) and motor (M1) cortex, and with 250–500 micron resolution along the line. We observed tangential diffusion in S1 and radial diffusion in M1, consistent with prior reports, but with the high radial resolution used here enabling us to identify the deep layers of S1—where high diffusion anisotropy was seen—as the source of the tangential diffusion, with low anisotropy in the upper layers. In M1, radial diffusion with moderate anisotropy was seen at nearly all cortical depths.

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