Abstract #0063

Multi-Dimensional Diffusion MRI of the Human Sciatic Nerve

Michael Pridmore¹, Filip Szczepankiewicz^2,3,4, Guillaume Gilbert⁵, Brian Johnson⁶, Carl-Fredrik Westin², and Richard D. Dortch^1,7

¹Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, ²Radiology, Harvard Medical School, Boston, MA, United States, ³Radiology, Brigham and Women's Hospital, Boston, MA, United States, ⁴Random Walk Imaging AB, Lund, Sweden, ⁵Philips Healthcare, Markham, ON, Canada, ⁶Philips Healthcare, Dallas, TX, United States, ⁷Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States

Multi-dimensional diffusion MRI is a promising new tool to assess tissue microstructure. Here, we developed a high-resolution protocol that overcomes the challenges of nerve imaging in humans (e.g., the influence of fat, short-T₂s) and translated the method to the sciatic nerve in the thigh. Preliminary results showed that measures of microscopic fractional anisotropy in sciatic nerve were 1) similar to reported measures in white matter and 2) were repeatable across scans in the same subject. Additional comparisons to conventional diffusion encodings of the sciatic nerve suggest that multi-dimensional diffusion MRI may yields more specific measures of nerve microstructure.

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