This work presents a new approach to mapping the fraction and spatial distribution of large axons (d>3μm) across white matter (WM) in the living human brain. By collecting high b-value (b=8000 s/mm2) diffusion MRI data at two diffusion times on a Connectome scanner, we were able to generate a new contrast specific to the characteristic signal decay of large axons at different diffusion times. Using this approach, we were able to identify and discriminate consistently some of the major WM pathways expected to carry the largest axons within the human brain. WM characterisation using TDR can offer important and practical clinical applications.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords