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Abstract #0076

Metabolic Imaging of Traumatic Brain Injuries Using Ultrahigh-Resolution 1H-MRSI

Tianyao Wang1, Jun Liu1, Tianxiao Zhang2, Ziyu Meng2, Danni Wang2, Ke Xue2, Yudu Li3,4, Rong Guo3,4, Yibo Zhao3,4, Xin Yu5, Zhi-Pei Liang3,4, and Yao Li2

1Radiology Department, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China, 2Institute for Medical Imaging Technology, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, 3Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 4Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 5Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States

Traumatic brain injury (TBI) is a significant public health problem that contributes to a large number of injury-induced deaths each year. MRSI has long been recognized as a powerful tool for detection of neurometabolic alterations induced by TBI; however, most existing MRSI studies of TBI are limited by low resolution which severely reduce the detection sensitivity. In this study, we performed MRSI scans on TBI patients using a newly developed ultrahigh-resolution 1H-MRSI technique. Our experimental study yielded very encouraging results and showed that ultrahigh-resolution MRSI can capture neurometabolic alterations induced by TBI effectively.

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