Abstract #0076

Metabolic Imaging of Traumatic Brain Injuries Using Ultrahigh-Resolution 1H-MRSI

Tianyao Wang¹, Jun Liu¹, Tianxiao Zhang², Ziyu Meng², Danni Wang², Ke Xue², Yudu Li^3,4, Rong Guo^3,4, Yibo Zhao^3,4, Xin Yu⁵, Zhi-Pei Liang^3,4, and Yao Li²

¹Radiology Department, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China, ²Institute for Medical Imaging Technology, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, ³Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁴Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁵Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States

Traumatic brain injury (TBI) is a significant public health problem that contributes to a large number of injury-induced deaths each year. MRSI has long been recognized as a powerful tool for detection of neurometabolic alterations induced by TBI; however, most existing MRSI studies of TBI are limited by low resolution which severely reduce the detection sensitivity. In this study, we performed MRSI scans on TBI patients using a newly developed ultrahigh-resolution ¹H-MRSI technique. Our experimental study yielded very encouraging results and showed that ultrahigh-resolution MRSI can capture neurometabolic alterations induced by TBI effectively.

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