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Abstract #0082

Advanced diffusion-weighted imaging reveals distinct neuropathological processes in concussed youth

Guido Ivan Guberman1, Jean-Christophe Houde2, Isabelle Gagnon3, Alain Ptito1, and Maxime Descoteaux2

1Neurology and Neurosurgery, McGill University, Montreal, QC, Canada, 2Computer Science, University of Sherbrooke, Sherbrooke, QC, Canada, 3Pediatrics, Montreal Children's Hospital, Montreal, QC, Canada

Because concussions are undetectable by conventional medical imaging, their diagnosis is dependent on symptoms, which can be unreliable. Conventional diffusion-weighted imaging (DWI) can detect abnormalities in concussed individuals, but lack specificity and hence cannot provide information about the underlying neuropathology, especially during the sub-acute stage of concussions where different neuropathologies occur simultaneously. In this study, we used emerging DWI methods to disambiguate the neuropathological basis of a common concussive symptom, memory problems. We found evidence of different white-matter neuropathologies in concussed youth which contributed differently to memory problems. This study is an important step towards developing neuropathologically-informed biomarkers of concussion.

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