Abstract #0081

In vivo magnetic resonance imaging demonstrates that subcutaneous administration angiotensin-(1-7) is neuroprotective following severe traumatic brain injury in mice

Zachary Janatpour¹, Asamoah Bosomtwi^2,3, Alexandru Korotcov^2,3, Andrew Knutsen^2,3, Shalini Jaiswal ^2,3, Nathanael Allison^2,4, Aviva J Symes^1,4, and Bernard Dardzinski^2,4

¹Pharmacology and Molecular Therapeutics, Program in Molecular and Cell Biology, Uniformed Services University, Bethesda, MD, United States, ²Radiology and Radiological Sciences, Uniformed Services University, Bethesda, MD, United States, ³Center for Neuroscience and Regenerative Medicine, Henry M. Jackson Foundation, Bethesda, MD, United States, ⁴Center for Neuroscience and Regenerative Medicine, Uniformed Services University, Bethesda, MD, United States

The effectiveness of angiotensin-(1-7), a novel peptide derivative of angiotensin II, for the treatment of traumatic brain injury in mice have been investigated using non-invasive MRI techniques. Our results demonstrate that treatment of mice with angiotensin-(1-7) after control cortical impact reduced lesion volume compared to saline-treated mice. The MRI data are validated by histological results. The observed data show for the first time that angiotensin-(1-7) has potential therapeutic use for TBI.

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