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Abstract #0080

Exploring static and dynamic functional connectivity differences between cognitively impaired and non-impaired active professional fighters

Xiaowei Zhuang1, Virendra Mishra1, Yang Zhengshi1, Karthik Sreenivasan1, Charles Bernick1, and Dietmar Cordes1,2

1Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States, 2University of Colorado Boulder, Boulder, CO, United States

Both static and dynamic FC differences between cognitively impaired and non-impaired active fighters were explored using resting-state fMRI. Reduced network strength in anterior default mode network and cerebellar network were observed in impaired fighters, as compared to the non-impaired fighters. Four dynamic FC states were identified with k-means clustering and abnormities in state 2 were observed in impaired fighters. Higher classification accuracy was obtained using dynamic FC matrices as input features to a non-linear classifier, as compared to using static FC matrices as input features, which demonstrates that the time-varying brain activities carry richer cognitive impairment-related information.

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