Abstract #0079

White matter changes caused by mild traumatic brain injury in mice

Lisa M Gazdzinski¹, Miranda Mellerup^1,2, Tong Wang^1,2, John G Sled^3,4, Brian J Nieman^3,4, and Anne L Wheeler^1,2

¹Neurosciences and Mental Health, Hospital for Sick Children, Toronto, ON, Canada, ²Physiology, University of Toronto, Toronto, ON, Canada, ³Mouse Imaging Centre, Hospital for Sick Children, Toronto, ON, Canada, ⁴Medical Biophysics, University of Toronto, Toronto, ON, Canada

White matter pathology following mild traumatic brain injury (mTBI) is complex and unlikely to be characterized by a single neuroimaging metric. DTI has been used to probe white matter microstructure, but is known to be non-specific. We show that the orientation dispersion index from the NODDI model may be more sensitive to white matter damage following mTBI in a mouse closed-skull impact model. Combined with quantitative susceptibility mapping, our data suggest minimal overt myelin loss, but progressive white matter injury, which may include myelin disruption, up to 6 weeks post-mTBI.

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