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Abstract #0078

Free water elimination is necessary to characterize Diffuse Axonal Injury in moderate Traumatic Brain Injury

Jacob Alappatt1, Drew Parker1, Abdol Aziz Ould Ismail1, Junghoon Kim2, and Ragini Verma1

1Penn Patho-Connectomics Lab, Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Molecular, Cellular, and Biomedical Sciences, CUNY School of Medicine, The City College of New York, New York, NY, United States

As the prevalence of diffusion MRI for clinical use grows, it is important to address the influence of injury-related extracellular water on the clinical interpretation of diffusion measures in conditions such as traumatic brain injury (TBI). The presence of extracellular free water from edema pollutes the estimation of diffusion measures, leading to flawed conclusions about the microstructure of the white matter. We demonstrate that Fernet, a robust single-shell free-water elimination method, can be used to decouple the effects of extracellular edema and tissue damage, to improve clinical understanding of the effects of injury on underlying white matter structure.

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