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Abstract #0084

Mild traumatic brain injury accelerates progressive brain ageing

Shuoqiu Gan1,2, Wen Shi2, Yingxiang Sun1, Lijun Bai2, and Ming Zhang1

1Department of Medical Imaging, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China, Xi'an, Shaanxi, China, 2The Key Laboratory of Biomedical Information Engineering, Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi’ an Jiaotong University, Xi’ an, 710049, China, Xi'an, Shaanxi, China

To analyze mild traumatic brain injury (mTBI) accelerating brain ageing, we trained a brain age prediction model based on diffuse tensor image (DTI) data by using machine learning method. Conducting a longitudinal observation from acute to chronic stages, we found that mTBI accelerated brain age process from acute stage to chronic stage. This prolonged abnormal brain ageing level could be predicted by information processing speed. In conclusion, mTBI persistently induces brain ageing process deviating from normal trajectory, and this process can be revealed by information processing speed at very early period after injury.

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