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Abstract #0085

Changes In White Matter Microstructure In Relation To Working Memory After Mild Traumatic Brain Injury: Multi-Shell Diffusion MRI Study

Sohae Chung1,2, Els Fieremans1,2, Xiuyuan Wang1,2, Dmitry S. Novikov1,2, Prin X. Amorapanth3, Steven R. Flanagan3, Joseph F. Rath3, and Yvonne W. Lui1,2

1Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, NYU School of Medicine, New York, NY, United States, 2Bernard and Irene Schwartz Center for Biomedical Imaging, NYU School of Medicine, New York, NY, United States, 3Department of Rehabilitation Medicine, NYU School of Medicine, New York, NY, United States

Working memory is a critical cognitive functions affected after mild traumatic brain injury (MTBI). We investigate associations between white matter (WM) microstructure and working memory, using multi-shell diffusion MRI and WAIS-IV subtests. The significant positive correlations observed in normal controls (NC) between tissue microstructure markers (fractional anisotropy (FA) and axonal water fraction (AWF)) with letter-number sequencing (LNS) were not present in MTBI. For MTBI, a significant positive correlation was observed between axial kurtosis (AK) and digit span backward (DSB), not seen in NC. These results show clear differences in the relationship between WM microstructure and working memory performance after injury.

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