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Abstract #0086

Acute effects of nicotine-free e-cigarette aerosol inhalation on vascular function detected by multi-parametric quantitative MRI

Alessandra Caporale1, Michael C Langham1, Shampa Chatterjee2, Alyssa C Johncola1, and Felix W Wehrli1

1Radiology, Laboratory for Structural, Physiologic and Functional Imaging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, 2Institute for Environmental Medicine and Department of Phisiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States

Electronic cigarette (e-cig) vaping has been causally associated with arterial stiffening, oxidative stress, and impaired vasodilatory capacity. Here we investigated acute effects of nicotine-free e-cig vaping in terms of aortic pulse-wave velocity, a marker of arterial stiffness, and measures of peripheral and neurovascular reactivity to induced hypoxia, by means of a quantitative MRI protocol. Flow mediated dilation, a marker of endothelial function, was significantly impaired after vaping; moreover, the peripheral vascular response to cuff-induced ischemia and neurovascular reactivity were altered. Considering the increasing use of e-cig among youth, these results underscore the urgency of further investigation.

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