Abstract #0106

3D R2* Mapping of the Placenta During Early Gestation Using Free-Breathing Multiecho Stack-of-Radial MRI at 3 T

Tess Armstrong^1,2, Dapeng Liu¹, Thomas Martin^1,2, Rinat Masamed¹, Carla Janzen³, Cass Wong¹, Teresa Chanlaw⁴, Sherin U. Devaskar⁴, Kyunghyun Sung^1,2, and Holden H. Wu^1,2

¹Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States, ²Physics and Biology in Medicine, University of California Los Angeles, Los Angeles, CA, United States, ³Obstetrics and Gynecology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, United States, ⁴Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, United States

Ischemic placental disease can lead to hypoxia and abnormal pregnancy outcomes. R₂* mapping using MRI can characterize placental hypoxia. However, conventional Cartesian MRI requires breath-holding which limits volumetric coverage, resolution, and signal-to-noise ratio. In addition, little is known about the nominal range of placental R₂* at 3T and during early gestation. Therefore, we developed and evaluated a new free-breathing 3D stack-of-radial (free-breathing radial) technique for full volume placental R₂* mapping at 3T. Free-breathing radial demonstrated good repeatability and established a nominal range of placental R₂* in pregnant subjects during early gestation at 3T.

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