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Abstract #0107

5-Minute Double-Echo in Steady-State with Separated Echoes for Comprehensive Whole-Joint Knee MRI Assessment with and without a Proton-Density-Weighted Sequence

Akshay Chaudhari1,2, Zhongnan Fang3, Murray Grissom1, Bragi Sveinsson4,5, Jeff P. Wood1, Christopher F. Beaulieu1,6, Edwin H. G. Oei7, Jarrett K. Rosenberg1, Feliks Kogan1, Jin Hyung Lee2,8,9,10, Marcus T. Alley1, Garry E. Gold1,2,6, Kathryn J. Stevens1,6, and Brian A. Hargreaves1,2,8

1Department of Radiology, Stanford University, Stanford, CA, United States, 2Department of Bioengineering, Stanford University, Stanford, CA, United States, 3LVIS Corporation, Palo Alto, CA, United States, 4Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 5Department of Radiology, Harvard Medical School, Boston, MA, United States, 6Department of Orthopaedic Surgery, Stanford University, Stanford, CA, United States, 7Department of Radiology & Nuclear Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands, 8Department of Electrical Engineering, Stanford University, Stanford, CA, United States, 9Department of Neurology & Neurological Sciences, Stanford University, Stanford, CA, United States, 10Department of Neurology, Stanford University, Stanford, CA, United States

Most knee MRI protocols require 20+ minutes of scan time, leading to interest in expedited protocols. Here, we first demonstrate in a study with 35 patients and 5 readers that for diagnostic knee MRI, a 3D 5-minute quantitative double-echo steady-state (qDESS) sequence has high agreement with the conventional sequences, where the addition of a proton-density-weighted sequence engenders near-perfect agreement. In a second study with 51 patients and 2 readers, we demonstrate that qDESS with two-fold enhanced slice resolution using deep-learning-based super-resolution and T2 maps has high agreement with the conventional sequences, where both methods have similar agreement with arthroscopic findings.

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