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Abstract #0108

3D chemical shift-encoded MRI for volume and composition quantification of abdominal adipose tissue during an overfeeding protocol in healthy volunteers

Angéline Nemeth1, Bérénice Segrestin2,3, Benjamin Leporq1, Kevin Seyssel4, Khuram Faraz1, Valérie Sauvinet2, Emmanuel Disse2,3, Pierre-Jean Valette5, Martine Laville2,3, Hélène Ratiney1, and Olivier Beuf1

1Univ Lyon, INSA‐Lyon, Université Claude Bernard Lyon 1, UJM-Saint Etienne, CNRS, Inserm, CREATIS UMR 5220, U1206, F69621, Lyon, France, 2Centre de Recherche en Nutrition Humaine Rhône-Alpes (CRNH-RA), Centre Hospitalier Lyon Sud, Pierre-Bénite, Lyon, France, 3Institut National de la Santé et de la Recherche Médicale Unit 1060, CarMeN Laboratory, Lyon 1 University, Oullins, France, 4Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, France, 5Hospices Civils de Lyon, Département d'imagerie digestive, CHU Edouard Herriot, Lyon, France

The aim of this work was to assess chemical shift-encoded MRI (CSE-MRI) method to quantify content and composition changes of fat storage in healthy volunteers during a 31 days overfeeding protocol while comparing CSE-MRI results with DEXA, MRS and Gas chromatography measurements. A total of 21 volunteers underwent a NMR protocol at 3T with an axial 3D CSE-MRI on abdominal region and spectroscopy acquired on subcutaneous adipose tissue, visceral adipose tissue and liver. The NMR protocol was used to analyze the volume and the fatty acid composition of abdominal adipose tissues, and the fat content in the liver.

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