Abstract #0121

Remyelination is less efficient in periventricular white matter lesions in Multiple Sclerosis

Matteo Tonietto¹, Emilie Poirion¹, Caroline Papeix², Michel Bottlaender³, Benedetta Bodini^1,4, and Bruno Stankoff^1,4

¹ICM - Brain & Spine Institute, Paris, France, ²Neurology Department, Pitie-Salpetriere Hospital, Paris, France, ³IMIV, CEA, Inserm, CNRS, Univ. Paris-Sud, Université Paris Saclay, CEA-SHFJ, Paris, France, ⁴Neurology Department, St Antoine Hospital, Paris, France

The objective of this study was to investigate the relationship between the extent of spontaneous remyelination and the distance from ventricular cerebrospinal fluid (CSF) in a group of multiple sclerosis patients. Dynamic remyelination was measured using longitudinal [11C]PiB positron emission tomography and found to be significantly reduced in periventricular white matter lesions, while becoming progressively more extensive with increasing distance from ventricles. Moreover, we found a positive correlation between periventricular remyelination and cortical thickness. These results suggest that CSF-linked factors might interfere with the spontaneous remyelination process in multiple sclerosis patients.

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