The objective of this study was to investigate the relationship between the extent of spontaneous remyelination and the distance from ventricular cerebrospinal fluid (CSF) in a group of multiple sclerosis patients. Dynamic remyelination was measured using longitudinal [11C]PiB positron emission tomography and found to be significantly reduced in periventricular white matter lesions, while becoming progressively more extensive with increasing distance from ventricles. Moreover, we found a positive correlation between periventricular remyelination and cortical thickness. These results suggest that CSF-linked factors might interfere with the spontaneous remyelination process in multiple sclerosis patients.
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