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Abstract #0121

Remyelination is less efficient in periventricular white matter lesions in Multiple Sclerosis

Matteo Tonietto1, Emilie Poirion1, Caroline Papeix2, Michel Bottlaender3, Benedetta Bodini1,4, and Bruno Stankoff1,4

1ICM - Brain & Spine Institute, Paris, France, 2Neurology Department, Pitie-Salpetriere Hospital, Paris, France, 3IMIV, CEA, Inserm, CNRS, Univ. Paris-Sud, Université Paris Saclay, CEA-SHFJ, Paris, France, 4Neurology Department, St Antoine Hospital, Paris, France

The objective of this study was to investigate the relationship between the extent of spontaneous remyelination and the distance from ventricular cerebrospinal fluid (CSF) in a group of multiple sclerosis patients. Dynamic remyelination was measured using longitudinal [11C]PiB positron emission tomography and found to be significantly reduced in periventricular white matter lesions, while becoming progressively more extensive with increasing distance from ventricles. Moreover, we found a positive correlation between periventricular remyelination and cortical thickness. These results suggest that CSF-linked factors might interfere with the spontaneous remyelination process in multiple sclerosis patients.

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