Abstract #0120

Test-retest Reliability of Myelin-Sensitive MRI Techniques

Kiara A. Kunimoto^1,2, Bryce L. Geeraert^2,3, R. Marc Lebel^2,4,5, and Catherine Lebel^2,4

¹Health Sciences Progam, University of Calgary, Calgary, AB, Canada, ²Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada, ³Biomedical Engineering Graduate Program, University of Calgary, Calgary, AB, Canada, ⁴Department of Radiology, University of Calgary, Calgary, AB, Canada, ⁵GE Healthcare, Calgary, AB, Canada

This project evaluated the reliability of quantitative inhomogeneous magnetization transfer (qihMT), a novel myelin-sensitive measure, compared to more common measures, magnetization transfer ratio (MTR) and fractional anisotropy (FA), in 10 healthy adults. A repeated measures ANOVA revealed no significant differences in measure means between scans in 18 white matter regions. Coefficients of variation (CV) demonstrated that FA had the highest reliability, followed by MTR and qihMT. The reduced reliability of qihMT observed here may be mitigated by further optimization of this novel sequence.

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