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Abstract #0119

A comparison between diffusion metrics, macromolecular proton fraction, and g-ratio for quantitative in vivo myelin mapping

Yu Veronica Sui1, Pippa Storey2, Alexey Samsonov3, and Mariana Lazar2,4

1New York University School of Medicine, New York, NY, United States, 2Department of Radiology, New York University School of Medicine, New York, NY, United States, 3Department of Radiology, University of Wisconsin at Madison, Madison, WI, United States, 4Bernard and Irene Schwartz Center for Biomedical Imaging, New York, NY, United States

Myelination as one of the most reliable indicators of postnatal brain maturation and cognitive ability, supports white matter function by facilitating efficient neural signaling and pathway remodeling. The current study aimed to compare in healthy young adults several recently developed myelin mapping metrics including g-ratio, macromolecular proton fraction, and metrics from diffusion tensor/kurtosis imaging. Relationships between these individual metrics and their specific sensitivity to different aspects of white matter microstructure are discussed.

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