Abstract #0118

A pediatric brain template for myelin water fraction and diffusion tensor imaging.

Sarah R. Morris^1,2,3, Richard Davis Holmes³, Adam V. Dvorak^1,2, Hanwen Liu^1,2, Irene Vavasour³, Silvia Mazabel⁴, Burkhard Mädler⁵, Shannon Kolind^1,2,3,6, David K. B. Li^3,6, Linda Siegel⁴, Christian Beaulieu⁷, Alex L. MacKay^1,3, and Cornelia Laule^1,2,3,8

¹Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, ²International Collaboration on Repair Discoveries, Vancouver, BC, Canada, ³Radiology, University of British Columbia, Vancouver, BC, Canada, ⁴Educational and Counseling Psychology, and Special Education, University of British Columbia, Vancouver, BC, Canada, ⁵Phillips Healthcare, Hamburg, Germany, ⁶Medicine, University of British Columbia, Vancouver, BC, Canada, ⁷Biomedical Engineering, University of Alberta, Edmonton, AB, Canada, ⁸Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada

Measuring pediatric brain myelination can provide insights into normal brain development as well as many pediatric brain disorders. We have created a myelin water and diffusion tensor template for healthy children aged 9-10 years to be used as a reference in imaging studies. Our template was produced using ANTs software to provide high-quality anatomical alignment of brain structures. ROI analysis revealed significant differences in myelin water fraction between children and adults. We found no significant correlation between myelin water fraction and diffusion tensor metrics across the ROIs investigated, highlighting the complementary information these two techniques provide.

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