Abstract #0117

Concurrent remyelination and susceptibility increase in new active MS lesions indicate early iron accrual

Shun Zhang^1,2, Yi Wang^2,3, Susan A. Gauthier⁴, and Thanh D. Nguyen²

¹Radiology, Tongji Hospital, Tongji Medical College, HUST, Wuhan, China, ²Radiology, Weill Cornell Medical College, New York, NY, United States, ³Biomedical Engineering, Cornell University, Ithaca, NY, United States, ⁴Neurology, Weill Cornell Medical College, New York, NY, United States

We reported initial results of an ongoing longitudinal study of new enhancing lesions using quantitative MRI including QSM, MWF and DTI. MS patients were followed five times during the first three months of lesion formation. We found a subset of lesions in which QSM rises rapidly and simultaneously with MWF and FA measurements, suggesting increasing iron accumulation within this period.

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