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Abstract #0116

Chronic MS lesions with hyperintense appearance on QSM demonstrate more myelin damage and are long-lasting

Shun Zhang1,2, Thanh D. Nguyen2, Yi Wang2,3, and Susan A. Gauthier4

1Radiology, Tongji Hospital, Tongji Medical College, HUST, Wuhan, China, 2Radiology, Weill Cornell Medical College, New York, NY, United States, 3Biomedical Engineering, Cornell University, Ithaca, NY, United States, 4Neurology, Weill Cornell Medical College, New York, NY, United States

We assessed longitudinal QSM and MWF changes in 307 chronic MS lesions from 41 patients over four years. Lesions were stratified into three groups: hyperintense rim on QSM (rim+), no rim (rim-) and isointense on QSM (QSM-). Rim+ lesions were found to have the lowest MWF. QSM lesions showed a decreasing trend while MWF remains relatively stable over the same period.

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