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Abstract #0115

Reproducibility of Practical Imaging-Based Myelin Biomarkers

Sehong Oh1 and Ken E. Sakaie2

1Division of Biomedical Engineering, Hankuk University of Foreign Studies, Yongin, Korea, Republic of, 2Imaging Institute, The Cleveland Clinic, Cleveland, OH, United States

Remyelination therapies are an emerging approach for treating multiple sclerosis, but development of these therapies is hampered by a lack of imaging biomarkers. Imaging with improved specificity to myelin, as compared to conventional MRI, have the potential to act as biomarkers, but current implementations can be time consuming. We examine the performance of fast version of myelin imaging from the perspective of reproducibility, a necessary prerequisite for use in proof-of-concept clinical trials of remyelinating agents.

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