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Abstract #0114

Comparison of Myelin- and Axon-Specific Imaging Modalities in Multiple Sclerosis

Sehong Oh1, Kunio Nakamura2, Kedar Mahajan3, Jacqueline Chen2, Mark J. Lowe4, Daniel Ontaneda3, Bruce D. Trapp2, and Ken E. Sakaie4

11Division of Biomedical Engineering, Hankuk University of Foreign Studies, Yongin, Korea, Republic of, 2Lerner Research Institute, The Cleveland Clinic, Cleveland, OH, United States, 3Neurological Institute, The Cleveland Clinic, Cleveland, OH, United States, 4The Cleveland Clinic, Cleveland, OH, United States

Multiple sclerosis (MS) is a chronic disease characterized by demyelination and neuronal/axonal pathology. Based on postmortem MRI-pathology correlations lesions found on conventional MRI do not exhibit expected demyelination. There is a need for imaging modalities that have better specificity for myelin, axonal density and axonal health. We compare the properties of fast variants of myelin-specific modalities (myelin water imaging, quantitative magnetization transfer and visualization of short transverse relaxation component) and of axon-specific measures from neurite orientation dispersion and density imaging. These comparisons constitute steps toward developing better imaging biomarkers for MS pathology.

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