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Abstract #0113

Volumetric Imaging of Myelin in Vivo using 3D Inversion-Recovery Ultrashort Echo Time Cones (3D IR-UTE-Cones) Magnetic Resonance Imaging

Ya-Jun Ma1, Adam Searleman1, Hyungseok Jang1, Shu-Juan Fan1, Jonathan Wong2, Jody Corey-Bloom3, Eric Chang1,2, and Jiang Du1

1Radiology, University of California, San Diego, San Diego, CA, United States, 2VA San Diego Healthcare System, San Diego, CA, United States, 3Neurosciences, University of California, San Diego, San Diego, CA, United States

To image myelin directly for whole brain on clinical scanners which would provide better characterization of multiple sclerosis (MS) lesions at diagnosis and in response to therapy, we propose a 3D adiabatic inversion recovery prepared ultrashort echo time cones (3D IR-UTE-Cones) sequence for volumetric myelin imaging in vivo with a clinical feasible scan time. The myelin imaging show clearly signal loss in MS lesions for both ex vivo and in vivo brain studies.

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