Abstract #0113

Volumetric Imaging of Myelin in Vivo using 3D Inversion-Recovery Ultrashort Echo Time Cones (3D IR-UTE-Cones) Magnetic Resonance Imaging

Ya-Jun Ma¹, Adam Searleman¹, Hyungseok Jang¹, Shu-Juan Fan¹, Jonathan Wong², Jody Corey-Bloom³, Eric Chang^1,2, and Jiang Du¹

¹Radiology, University of California, San Diego, San Diego, CA, United States, ²VA San Diego Healthcare System, San Diego, CA, United States, ³Neurosciences, University of California, San Diego, San Diego, CA, United States

To image myelin directly for whole brain on clinical scanners which would provide better characterization of multiple sclerosis (MS) lesions at diagnosis and in response to therapy, we propose a 3D adiabatic inversion recovery prepared ultrashort echo time cones (3D IR-UTE-Cones) sequence for volumetric myelin imaging in vivo with a clinical feasible scan time. The myelin imaging show clearly signal loss in MS lesions for both ex vivo and in vivo brain studies.

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