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Abstract #0112

3D Inversion Recovery Ultrashort Echo Time (3D IR-UTE) Magnetic Resonance Imaging of Myelin in Traumatic Brain Injury – a Feasibility Study

Ya-Jun Ma1, Adam Searleman1, Shanshan Wang1, Hyungseok Jang1, Jonathan Wong2, Eric Chang1,2, Brian Head1, and Jiang Du1

1University of California, San Diego, San Diego, CA, United States, 2VA San Diego Healthcare System, San Diego, CA, United States

Reduced myelination has been observed in rodents and humans after mild traumatic brain injury (mTBI). However, conventional MR imaging sequences cannot directly detect any signal from myelin. In this study, we aimed to evaluate a 3D IR-UTE sequence for selective imaging of myelin in mice using a standard controlled cortical impact (CCI) model of mTBI with histological confirmation. To demonstrate the clinical feasibility, a translational 3D IR-UTE technique was developed and applied to healthy volunteers and mTBI patients at 3T. The preliminary results demonstrate the feasibility of volumetric myelin mapping using the 3D IR-UTE sequences at 7T and 3T.

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