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Abstract #0124

Multi-parameter quantitative MRI reveals common distribution of myelin in ex-vivo chimpanzee and in-vivo human brains

Daniel Papp1, Nicole Eichert1, Colin Reveley1, Stuart Clare1, and Rogier B Mars1,2

1Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 2Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, Netherlands

Post-mortem investigations of tissue properties can dramatically extend the biological information that can be obtained from bodies or tissue that cannot be easily investigated in-vivo, as is the case for the majority of species of interest to comparative neuroscience. Here, we show the potential of a quantitive MRI method, multi-parameter mapping, to obtain high-resolution information about tissue properties of large non-human primates that generally cannot be studied anatomically. We compare myelination indices, derived from ex-vivo chimpanzee data at 7T to those derived from in-vivo human data at 3T.

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