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Abstract #0125

Effects of myelin on the water resonance line-shape in postmortem mouse brain

Sean Foxley1, Gregory S Karczmar1, Brian Popko2, Pedro Brugarolas3,4, Gregg Wildenberg5, Vandana Sampathkumar5, and Narayanan Kasthuri5

1Department of Radiology, University of Chicago, Chicago, IL, United States, 2Department of Neurology, University of Chicago, Chicago, IL, United States, 3Department of Radiology, Harvard Medical School, Boston, MA, United States, 4Gordon Center for Medical Imaging, Massachusetts General Hospital, Boston, MA, United States, 5Department of Neurobiology, University of Chicago, Chicago, IL, United States

Dysmyelinating diseases are characterized by abnormal myelin formation and function. Such microstructural abnormalities in myelin have been demonstrated to produce measurable effects on the MR signal. This work examines these effects from post-mortem fixed control and shiverer mouse brains on voxel-wise, high-resolution water spectra acquired using a multi-gradient echo pulse sequence. Results demonstrate that components of the spectra are differentially affected by myelin concentration. This suggests that water proton spectra may be sensitive to the tissue microenvironment, specifically myelin, and could serve as potential MRI based biomarkers of dysmyelinating diseases.

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