Abstract #0128

GagCEST at 3T Can Detect Cartilage Differences Between Healthy and OA Subjects

Elka Rubin¹, Lauren Watkins², Valentina Mazzoli^1,3, Arjun D Desai¹, Gabe Ho², Feliks Kogan¹, Scott Ulrich⁴, Julie Kolesar², Scott Delp^2,4,5, Gary Beaupre³, and Garry E Gold^1,2

¹Department of Radiology, Stanford University, Stanford, CA, United States, ²Department of Bioengineering, Stanford University, Stanford, CA, United States, ³Musculoskeletal Research Laboratory, VA Palo Alto Healthcare System, Palo Alto, CA, United States, ⁴Department of Mechanical Engineering, Stanford University, Stanford, CA, United States, ⁵Orthopaedic Surgery, Stanford, Stanford, CA, United States

Chemical exchange saturation transfer of GAG (gagCEST) is a quantitative MR technique that is a useful biomarker for assessing GAG content at 7T. However, its utility at 3T remains unclear. In this study, we compare gagCEST asymmetry values of healthy and osteoarthritic subjects scanned at 3T. Comparisons between healthy and OA subjects indicate a significant difference in the average gagCEST signal across the medial and lateral anterior and medial weight-bearing regions of the femoral cartilage. The results of this study suggest that there is potential for use of gagCEST in the study of OA at 3T.

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