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Abstract #0128

GagCEST at 3T Can Detect Cartilage Differences Between Healthy and OA Subjects

Elka Rubin1, Lauren Watkins2, Valentina Mazzoli1,3, Arjun D Desai1, Gabe Ho2, Feliks Kogan1, Scott Ulrich4, Julie Kolesar2, Scott Delp2,4,5, Gary Beaupre3, and Garry E Gold1,2

1Department of Radiology, Stanford University, Stanford, CA, United States, 2Department of Bioengineering, Stanford University, Stanford, CA, United States, 3Musculoskeletal Research Laboratory, VA Palo Alto Healthcare System, Palo Alto, CA, United States, 4Department of Mechanical Engineering, Stanford University, Stanford, CA, United States, 5Orthopaedic Surgery, Stanford, Stanford, CA, United States

Chemical exchange saturation transfer of GAG (gagCEST) is a quantitative MR technique that is a useful biomarker for assessing GAG content at 7T. However, its utility at 3T remains unclear. In this study, we compare gagCEST asymmetry values of healthy and osteoarthritic subjects scanned at 3T. Comparisons between healthy and OA subjects indicate a significant difference in the average gagCEST signal across the medial and lateral anterior and medial weight-bearing regions of the femoral cartilage. The results of this study suggest that there is potential for use of gagCEST in the study of OA at 3T.

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