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Abstract #0140

Quantitative MRI Measurements can Distinguish Myositis From Healthy Control Muscle.

Matthew Farrow1,2, Ai Lyn Tan1,2, Paul Emery1,2, Maya Buch1,2, Andrew Grainger1,2, Steven Tanner2, and John Biglands2

1Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds, United Kingdom, 2NIHR Leeds Biomedical Research Centre, Leeds, United Kingdom

Myositis is an autoimmune inflammatory muscle disease which can decrease quality of life and increase mortality. Clinical presentation includes muscle weakness, changes in muscle microstructure, myosteatosis and myalgia. Current diagnosis is reliant on subjective clinical examinations, blood tests and invasive biopsies. Quantitative MRI techniques such as diffusion and fat fraction measurements are sensitive to changes within the muscle. 10 myositis patients and 16 healthy controls underwent scans of the thigh. Significant differences were found in fat fraction and diffusion measurements between myositis patients and healthy controls, implying these measures have potential as biomarkers in the diagnosis and management of myositis.

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