Abstract #0145

A Novel Approach for Improved CEST Imaging with Real-Time Frequency Drift Correction

Ruibin Liu¹, Hongxi Zhang², Weiming Niu², Can Lai², Qiuping Ding¹, Weibo Chen³, Sayuan Liang⁴, Jinyuan Zhou⁵, Dan Wu^1,5, and Yi Zhang^1,5

¹Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, ²Department of Radiology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China, ³Philips Healthcare, Shanghai, China, ⁴Clinical Research Board, Philips Research China, Shanghai, China, ⁵Department of Radiology, Johns Hopkins University, Baltimore, MD, United States

Chemical Exchange Saturation Transfer (CEST) imaging is highly sensitive to temporal B₀ drift. Here, we proposed a novel frequency-stabilized CEST (FS-CEST) imaging sequence by adding a frequency stabilization module to the conventional non-frequency-stabilized CEST (NFS-CEST) sequence for correcting artifacts due to B₀ drift in real time. The FS-CEST sequence was implemented in phantoms and 26 human volunteers, and generated substantially more stable magnetization transfer ratio asymmetry (MTR_asym) spectra and amide proton transfer weighted (APTw) images than the conventional NFS-CEST sequence. The FS-CEST sequence provides an effective approach for B₀ drift correction without additional scan time.

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