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Abstract #0145

A Novel Approach for Improved CEST Imaging with Real-Time Frequency Drift Correction

Ruibin Liu1, Hongxi Zhang2, Weiming Niu2, Can Lai2, Qiuping Ding1, Weibo Chen3, Sayuan Liang4, Jinyuan Zhou5, Dan Wu1,5, and Yi Zhang1,5

1Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, 2Department of Radiology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China, 3Philips Healthcare, Shanghai, China, 4Clinical Research Board, Philips Research China, Shanghai, China, 5Department of Radiology, Johns Hopkins University, Baltimore, MD, United States

Chemical Exchange Saturation Transfer (CEST) imaging is highly sensitive to temporal B0 drift. Here, we proposed a novel frequency-stabilized CEST (FS-CEST) imaging sequence by adding a frequency stabilization module to the conventional non-frequency-stabilized CEST (NFS-CEST) sequence for correcting artifacts due to B0 drift in real time. The FS-CEST sequence was implemented in phantoms and 26 human volunteers, and generated substantially more stable magnetization transfer ratio asymmetry (MTRasym) spectra and amide proton transfer weighted (APTw) images than the conventional NFS-CEST sequence. The FS-CEST sequence provides an effective approach for B0 drift correction without additional scan time.

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