Abstract #0144

Homogenous Excitation in Whole Brain CEST: Combination of Snapshot CEST and Multiple Interleaved Mode Saturation

Andrzej Liebert¹, Moritz Zaiss², Rene Gumbrecht³, Patrick Liebig³, Benjamin Schmitt³, Frederik Laun¹, Arnd Doerfler⁴, Michael Uder¹, and Armin M. Nagel¹

¹Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, ²Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, ³Siemens Healthcare GmbH, Erlangen, Germany, ⁴Department of Neuroradiolohy, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany

To perform Chemical Exchange Saturation Transfer MRI of the whole brain a homogeneous saturation and fast readout are required. To achieve a fast and robust 3D acquisition a spiral-centric-reordered GRE readout was used. In addition, a Multiple Interleaved Mode Saturation scheme was applied to mitigate B₁⁺-inhomogeneity effects of the CEST saturation. Combination of these two methods allows acquiring a homogenous CEST contrast in a volume of approximately 220x220x45mm³ within an acquisition time of 7 min 26s.

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