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Abstract #0148

Fat corrected APT-CEST in the human breast at 7 Tesla: application to mamma carcinoma and dependency on menstrual cycle

Ferdinand Zimmermann1,2, Andreas Korzowski1, Lisa Carmen Loi3, Johannes Sebastian Breitling1,2,4, Jan-Eric Meissner1, Moritz Zaiss5, Sebastian Bickelhaupt3, Heinz-Peter Schlemmer3, Mark E. Ladd1, Peter Bachert1,2, Daniel Paech3, Sarah Schott6, and Steffen Goerke1

1Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Department of Physics and Astronomy, University of Heidelberg, Heidelberg, Germany, 3Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 4Max Planck Institute for Nuclear Physics, Heidelberg, Germany, 5High‐field Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany, 6Department of Gynecology and Obstetrics, University Hospital Heidelberg, Heidelberg, Germany

The fat correction method enables robust APT-CEST quantification in the human breast and proved its suitability for examinations in vivo. We present to the extent of our knowledge the first APT-CEST contrast corrected for fat signal contribution, spillover, B1 field inhomogeneities and T1 relaxation in a breast cancer patient. The CEST contrast increased threefold compared to the measurement of a healthy volunteer. Repeated CEST imaging over the course of one menstrual cycle in one healthy woman did not reveal a hormonal correlation of APT contrast. A clinical study in healthy premenopausal volunteers will now investigate the dependency on menstrual cycle.

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