Abstract #0148

Fat corrected APT-CEST in the human breast at 7 Tesla: application to mamma carcinoma and dependency on menstrual cycle

Ferdinand Zimmermann^1,2, Andreas Korzowski¹, Lisa Carmen Loi³, Johannes Sebastian Breitling^1,2,4, Jan-Eric Meissner¹, Moritz Zaiss⁵, Sebastian Bickelhaupt³, Heinz-Peter Schlemmer³, Mark E. Ladd¹, Peter Bachert^1,2, Daniel Paech³, Sarah Schott⁶, and Steffen Goerke¹

¹Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ²Department of Physics and Astronomy, University of Heidelberg, Heidelberg, Germany, ³Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ⁴Max Planck Institute for Nuclear Physics, Heidelberg, Germany, ⁵High‐field Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany, ⁶Department of Gynecology and Obstetrics, University Hospital Heidelberg, Heidelberg, Germany

The fat correction method enables robust APT-CEST quantification in the human breast and proved its suitability for examinations in vivo. We present to the extent of our knowledge the first APT-CEST contrast corrected for fat signal contribution, spillover, B₁ field inhomogeneities and T₁ relaxation in a breast cancer patient. The CEST contrast increased threefold compared to the measurement of a healthy volunteer. Repeated CEST imaging over the course of one menstrual cycle in one healthy woman did not reveal a hormonal correlation of APT contrast. A clinical study in healthy premenopausal volunteers will now investigate the dependency on menstrual cycle.

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