Sodium salicylate (NaSA), a nonsteroidal anti-inflammatory drug and the main metabolite of aspirin, accumulates specifically in inflamed tissue. Since NaSA can be detected with CEST-MRI at millimolar concentrations, we investigated the use of NaSA-enhanced CEST MRI for in vivo mapping of brain inflammation, induced by intracerebral injection of lipopolysaccharide in mice. NaSA-CEST shows signal enhancement in the inflamed LPS-injected hemisphere, which was not observed in two control groups. NaSA-CEST exhibits distinct signal kinetics and enhanced regions from that of Gd-enhanced MRI, and shows correlations with histological staining of inflammatory markers, indicating its potential as a new platform for imaging neuroinflammation.
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