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Abstract #0149

NaSA-CEST MRI: comparison with Gd-enhanced contrast for imaging brain inflammation

Xiaolei Song1,2, Yanrong Chen1,3, Chenwang Jin1,2, Tao Liu1,2, Chengyan Chu1,2, Yuguo Li1, Yue Yuan1,2, Xiaowei He3, Piotr Walczak1,2, and Jeff WM Bulte1,2

1Russell H. Morgan Dept. of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, 2Cellular Imaging Section, Institute for Cell Engineering, Johns Hopkins University, Baltimore, MD, United States, 3Dept. of Information Sciences and Technology, Northwest University, Xi'an, China

Sodium salicylate (NaSA), a nonsteroidal anti-inflammatory drug and the main metabolite of aspirin, accumulates specifically in inflamed tissue. Since NaSA can be detected with CEST-MRI at millimolar concentrations, we investigated the use of NaSA-enhanced CEST MRI for in vivo mapping of brain inflammation, induced by intracerebral injection of lipopolysaccharide in mice. NaSA-CEST shows signal enhancement in the inflamed LPS-injected hemisphere, which was not observed in two control groups. NaSA-CEST exhibits distinct signal kinetics and enhanced regions from that of Gd-enhanced MRI, and shows correlations with histological staining of inflammatory markers, indicating its potential as a new platform for imaging neuroinflammation.

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