Abstract #0150

Proton exchange rate increases in MS lesions

Mehran Shaghaghi¹, Weiwei Chen², Alessandro Scotti^3,4, Haiqi Ye⁵, Yan Zhang⁵, Wenzhen Zhu², and Kejia Cai^3,6

¹Radiology, University of Illinois, Chicago, IL, United States, ²Department of Radiology, Huazhong University of Science & Technology, China, China, ³Radiology, University of Illinois at Chicago, Chicago, IL, United States, ⁴Bioengieering, University of Illinois at Chicago, Chicago, IL, United States, ⁵Huazhong University of Science & Technology, Wuhan, China, ⁶Bioenginnering, University of Illinois at Chicago, Chicago, IL, United States

We have evaluated the performance of magnetic resonance proton exchange (K_ex) imaging in vivo in characterization of gray matter, white matter as well as MS lesions. With informed consent, 10 control and 8 MS diagnosed subjects underwent a brain MRI on a 3T clinical-scanner. K_ex maps were generated by pixel-wise ﬁtting of the omega plot constructed from four different saturation power (B₁=1, 2, 3 & 4 µT). K_ex values from gray matter (GM), white matter (WM) and lesions were calculated, and two-tailed paired Student’s T-test was used to classify each group. K_ex was able to demarcates each region. The combined use of K_ex mapping has potential to improve the early and speciﬁc diagnosis of MS.

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