Abstract #0154

Impact of unilateral carotid artery stenosis on white matter fiber orientation effects of mq-BOLD derived oxygen extraction fraction

Stephan Kaczmarz^1,2, Jens Goettler^1,2,3, Andreas Hock⁴, Claus Zimmer¹, Fahmeed Hyder², and Christine Preibisch^1,5

¹Department of Neuroradiology, Technical University of Munich, Munich, Germany, ²MRRC, Yale University, New Haven, CT, United States, ³Clinic for Radiology, Technical University of Munich, Munich, Germany, ⁴Philips Healthcare, Hamburg, Germany, ⁵Clinic for Neurology, Technical University of Munich, Munich, Germany

Assessment of relative oxygen extraction fraction (rOEF) in white matter (WM) by multiparametric quantitative-BOLD (mq-BOLD) has highest clinical relevance, but was so far limited due to known WM anisotropy effects. Here, we present data from a clinical study in 29 internal carotid artery stenosis (ICAS) patients and 30 age-matched healthy controls (HC). The major aim was to characterise the ICAS impact on T₂*, T₂, R₂’, rCBV and rOEF orientation dependencies in WM. Our results show very similar rOEF orientation dependencies for ICAS-patients compared to HC and low average rOEF orientation errors of 4.5% indicating potentially meaningful rOEF evaluations in WM.

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