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Abstract #0154

Impact of unilateral carotid artery stenosis on white matter fiber orientation effects of mq-BOLD derived oxygen extraction fraction

Stephan Kaczmarz1,2, Jens Goettler1,2,3, Andreas Hock4, Claus Zimmer1, Fahmeed Hyder2, and Christine Preibisch1,5

1Department of Neuroradiology, Technical University of Munich, Munich, Germany, 2MRRC, Yale University, New Haven, CT, United States, 3Clinic for Radiology, Technical University of Munich, Munich, Germany, 4Philips Healthcare, Hamburg, Germany, 5Clinic for Neurology, Technical University of Munich, Munich, Germany

Assessment of relative oxygen extraction fraction (rOEF) in white matter (WM) by multiparametric quantitative-BOLD (mq-BOLD) has highest clinical relevance, but was so far limited due to known WM anisotropy effects. Here, we present data from a clinical study in 29 internal carotid artery stenosis (ICAS) patients and 30 age-matched healthy controls (HC). The major aim was to characterise the ICAS impact on T2*, T2, R2’, rCBV and rOEF orientation dependencies in WM. Our results show very similar rOEF orientation dependencies for ICAS-patients compared to HC and low average rOEF orientation errors of 4.5% indicating potentially meaningful rOEF evaluations in WM.

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