Friedreich’s ataxia is a rare disease involving degenerative processes within white matter fiber tracts, spinal nerves and the cerebellum. A correlation of patients’ clinical status and superior cerebellar peduncle atrophy has been shown in MR volumetry studies. The ongoing ultra-high field study presented here assesses the degeneration of the superior cerebellar peduncle in Friedreich’s ataxia with quantitative MR parameters – susceptibility, diffusion anisotropy, and T2 and T1 relaxometry. Statistically significant differences between fractional anisotropy as well as T2 values in patients and healthy controls could be observed, indicating that these quantitative MRI methods potentially provide valuable biomarkers to assess the course of Friedreich’s ataxia.
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