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Abstract #0156

Glucose Uptake in Mouse Brain Detected by MRI Frequency Shifts with a Jump-Return Sequence

Zhiliang Wei1,2, Haifeng Zeng1,2, Lin Chen1,2, Kannie Chan1,2,3, Xiang Xu1,2, Issel Anne Lim1,2, Xu Li1,2, Hanzhang Lu1,2, Peter C.M. van Zijl1,2, and Jiadi Xu1,2

1Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States, 3Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, China

Neuronal activity relies on glucose metabolism for energy maintenance and abnormalities in glucose uptake and metabolism constitute a potential biomarker for many disorders, including neurodegenerative diseases. Existing MRI techniques for monitoring glucose uptake and transportation often suffer from insufficient detection sensitivity. Here, we demonstrate a jump-return MRI (JR-MRI) method with high sensitivity for monitoring glucose uptake via tracing the water-frequency shift induced by chemical exchange. Conventional MRS was performed to validate the delivery of glucose to the brain.

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