Abstract #0156

Glucose Uptake in Mouse Brain Detected by MRI Frequency Shifts with a Jump-Return Sequence

Zhiliang Wei^1,2, Haifeng Zeng^1,2, Lin Chen^1,2, Kannie Chan^1,2,3, Xiang Xu^1,2, Issel Anne Lim^1,2, Xu Li^1,2, Hanzhang Lu^1,2, Peter C.M. van Zijl^1,2, and Jiadi Xu^1,2

¹Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States, ³Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, China

Neuronal activity relies on glucose metabolism for energy maintenance and abnormalities in glucose uptake and metabolism constitute a potential biomarker for many disorders, including neurodegenerative diseases. Existing MRI techniques for monitoring glucose uptake and transportation often suffer from insufficient detection sensitivity. Here, we demonstrate a jump-return MRI (JR-MRI) method with high sensitivity for monitoring glucose uptake via tracing the water-frequency shift induced by chemical exchange. Conventional MRS was performed to validate the delivery of glucose to the brain.

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