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Abstract #0164

Diffusion MRI in the unfolded hippocampus

Uzair Hussain1, Jordan DeKraker1,2,3, Corey A. Baron1,2,4,5, and Ali R. Khan1,2,4,5

1Centre for Functional and Metabolic Mapping, Robarts Research Institute, Western University, London, ON, Canada, 2Neuroscience Graduate Program, Western University, London, ON, Canada, 3The Brain and Mind Institute, Western University, London, ON, Canada, 4Department of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, 5School of Biomedical Engineering, Western University, London, ON, Canada

The hippocampus is of high interest to the research community due to its involvement in many neurological disorders. However, in-vivo imaging, particularly diffusion weighted imaging, is challenging due to the hippocampus’ complicated curved geometry and small size. We address these challenges with an approach that ‘unfolds’ the hippocampus into a thin sheet. This allows migration of the diffusion data into this unfolded hippocampus, which enables visualization of microstructural sensitive diffusion parameters in a space where hippocampal subfields can be readily distinguished.

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