Abstract #0164

Diffusion MRI in the unfolded hippocampus

Uzair Hussain¹, Jordan DeKraker^1,2,3, Corey A. Baron^1,2,4,5, and Ali R. Khan^1,2,4,5

¹Centre for Functional and Metabolic Mapping, Robarts Research Institute, Western University, London, ON, Canada, ²Neuroscience Graduate Program, Western University, London, ON, Canada, ³The Brain and Mind Institute, Western University, London, ON, Canada, ⁴Department of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, ⁵School of Biomedical Engineering, Western University, London, ON, Canada

The hippocampus is of high interest to the research community due to its involvement in many neurological disorders. However, in-vivo imaging, particularly diffusion weighted imaging, is challenging due to the hippocampus’ complicated curved geometry and small size. We address these challenges with an approach that ‘unfolds’ the hippocampus into a thin sheet. This allows migration of the diffusion data into this unfolded hippocampus, which enables visualization of microstructural sensitive diffusion parameters in a space where hippocampal subfields can be readily distinguished.

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