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Abstract #0175

Glial and axonal changes in mouse models of disease investigated with diffusion-weighted magnetic resonance spectroscopy at 11.7 T

Guglielmo Genovese1,2, Mathieu Santin1,2, Marco Palombo3, Julien Valette4, Clemence Ligneul5, Marie-Stéphane Aigrot2,6, Mehdi Felfli1, Nasteho Abdoulkader1, Dominique Langui2,6, Aymeric Millecamps2,6, Anne Baron-Van Evercooren2, Bruno Stankoff2, Stéphane Lehericy1,2, Alexandra Petiet1,2, and Francesca Branzoli1,2

1Centre de NeuroImagerie de Recherche (CENIR), Institut du Cerveau et de la Moelle épinère (ICM), Paris, France, 2Sorbonne Université, UMR S 1127, Inserm U 1127, CNRS UMR 7225, Institut du Cerveau et de la Moelle épinère (ICM), Paris, France, 3Department of Computer Science and Centre for Medical Image Computing, University College of London (UCL), London, United Kingdom, 4Institute of biomedical imaging, Atomic Energy and Alternative Energies Commission (CEA), Fontenay-aux-Roses, France, 5Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, Lisbon, Portugal, 6Core Facility ICM.Quant, Institut du Cerveau et de la Moelle épinère (ICM), Paris, France

The goal of this study was to evaluate the alterations of white matter microstructure in two different mouse models of white matter disease: the cuprizone (CPZ) model of multiple sclerosis and the Plp1 overexpressing (PLP-tg66) model of Pelizeaus-Merzbacher disease. To this end, we employed diffusion-weighted MR spectroscopy (DW-MRS) to measure concentrations and apparent diffusion coefficients of several metabolites in the corpus callosum of wild-type, CPZ and PLP-tg66 mice at 11.7 T. DW-MRS markers of axonal and glial degeneration were compared with histological measures.

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