Abstract #0176

Elevated brain glutamate levels in type 1 diabetes

Evita Wiegers¹, Hanne Rooijackers², Jack van Asten¹, Cees Tack², Arend Heerschap¹, Bastiaan de Galan², and Marinette van der Graaf^1,3

¹Radiology and Nuclear Medicine, Radboud university medical center, Nijmegen, Netherlands, ²Internal Medicine, Radboud university medical center, Nijmegen, Netherlands, ³Pediatrics, Radboud university medical center, Nijmegen, Netherlands

Type 1 diabetes affects the structure and functioning of the brain, but the neurochemical mediators that may accompany these negative effects are largely unknown. We investigated brain metabolite levels with ¹H MRS in patients with type 1 diabetes and normal awareness of hypoglycemia, patients with impaired awareness of hypoglycemia (IAH) and non-diabetic controls. Brain glutamate levels were elevated in type 1 diabetes and correlated with glycemic control and age of disease onset, but not with burden of hypoglycemia as reflected by IAH. This suggests a potential role for glutamate as early marker of hyperglycemia-induced cerebral decline in type 1 diabetes.

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